2009 – 2014

Mission Statement

Promote interdisciplinary and translational research that defines sex and gender differences in pathophysiology, health care delivery, and treatment effectiveness to reduce cardiovascular disease burden.

Members:

  • Noel Bairey Merz, MD, FACC, Cedars-Sinai Medical Center (Network Chair)
  • Virginia M. Miller, PhD, Mayo Clinic (Network Co-Chair)
  • Sarah L. Berga, MD, Wake Forest University
  • Jay R. Kaplan, PhD, Wake Forest University
  • Pamela Ouyang, MD, Johns Hopkins University
  • Jane F. Reckelhoff, PhD, University of Mississippi

Program Director

Monica Mallampalli, PhD, MSc.

  • Janet Rich-Edwards, ScD, Brigham and Women’s Hospital
  • Leslee J. Shaw, PhD, Emory University
  • Meir Steiner, MD, PhD, FRCPC, McMaster University
  • Doris A. Taylor, PhD, Texas Heart Institute
  • Clinton Webb, PhD, Georgia Regents University
  • Nanette K. Wenger, MD, MACC, MACP, FAHA, Emory University

Peer-reviewed Publications and Reviews

  • Virginia M. Miller et al., “Strategies and Methods to Study Sex Differences in Cardiovascular Structure and Function: A guide for Basic Scientists.” Biology of Sex Differences 2, no. 14 (2011). PMID:22152231
  • Nanette K. Wenger, “Cardiovascular Disease: The Female Heart is Vulnerable: A Call to Action from the 10Q Report.” Clinical Cardiology 35, no. 3 (2012): 134-135. PMID:22389116
  • Styliani Goulopoulou et al., “Pregnancy Reduces RhoA/Rho Kinase and Protein Kinase C Signaling Pathways Downstream of Thromboxane Receptor Activation in the Rat Uterine Artery.” American Journal of Physiology – Heart and Circulatory Physiology 302, no. 12 (2012): H2477-2488. PMID:22542618
  • Styliani Goulopoulou et al., “Toll-like Receptor 9 Activation: A Novel Mechanism Linking Placenta-derived Mitochondrial DNA and Vascular Dysfunction in Pre-eclampsia.” Clinical Science (London, England) 123, no. 7 (2012): 429-435. PMID:22671429
  • Nanette K. Wenger, “Are We There Yet? Closing the Gender Gap in Coronary Heart Disease Recognition, Management and Outcomes.” Expert Review of Cardiovascular Therapy 11, no. 11 (2013): 1447-1450. PMID:24160575
  • Jennifer J. Stuart et al., “Maternal Recall of Hypertensive Disorders in Pregnancy: A Systematic Review.” Journal of Women’s Health (Larchmt) 22, no. 1 (2013): 37-47. PMID:23215903
  • Jennifer A. Thompson and R. Clinton Webb. “Potential Role of Toll-like Receptors in Programming of Vascular Dysfunction.” Clinical Science (London, England) 125, no. 1 (2013): 19-25. PMID:23485061
  • Tracey L. Weissgerber et al., “Hypertension in Pregnancy is a Risk Factor for Peripheral Arterial Disease Decades after ” Atherosclerosis 229, no. 1 (2013): 212-216. PMID:23485061
  • Kathryn M. Spitler, Takayuki Matsumoto, and R. Clinton Webb, “Suppression of Endoplasmic Reticulum Stress Improves Endothelium-Dependent Contractile Responses in Aorta of the Spontaneously Hypertensive Rat.” American Journal of Physiology – Heart and Circulatory Physiology 305, no. 3 (2013): H344-H353. PMID:23709602
  • Andrea G. Kattah et al., “Hypertension in Pregnancy is a Risk Factor for Microalbuminuria Later in Life” Journal of Clinical Hypertension 15, no. 9 (2013): 617-623. PMID:24034653
  • Cameron G. McCarthy et al., “Toll-like Receptors and Damage-Associated Molecular Patterns: Novel Links between Inflammation and Hypertension.” American Journal of Physiology – Heart and Circulatory Physiology 306, no. 2 (2014):H184-196. PMID:24163075
  • Stylani Goulopoulou and R. Clinton Webb, “Symphony of Vascular Contraction: How Smooth Muscle Cells Lose Harmony to Signal Increased Vascular Resistance in Hypertension.” Hypertension 63, no. 3 (2014): e33-39. PMID:24470463
  • Kathryn M. Spitler and R. Clinton Webb, “Endoplasmic Reticulum Stress Contributes to Aortic Stiffening via Proapoptotic and Fibrotic Signaling Mechanisms.” Hypertension 63, no. 3 (2014): e40-45. PMID:24379182
  • Wenger, NK. “Recognizing pregnancy-associated cardiovascular risk factors.” The American Journal of Cardiology 113 (2014): 406-409. PMID:24188889
  • Pamela Ouyang et al., “Strategies and Methods to Study Female-Specific Cardiovascular Health and Disease: A Guide for Clinical Scientists.” Biology of Sex Differences 7, no. 19 (2016) PMID:27034774
  • Nanette K. Wenger et al., “Strategies and Methods for Clinical Scientists to Study Sex-Specific Cardiovascular Health and Disease in Women.” Journal of American College of Cardiology 67, no. 18 (2016): 2186-2188. PMID: 27151351
  • Janet Wei et al., “Diastolic dysfunction measured by cardiac magnetic resonance imaging in women with signs and symptoms of ischemia but no obstructive coronary artery disease.” International Journal of Cardiology, 220 (2016): 775-780. PMID: 27394973

Published Abstracts

  • Carmen G. McCarthy et al., “Chronic Toll-like Receptor 9 Activation Mediates Heightened Vascular Contractility via Attenuated NOS Activity in Isolated Aortic Segments.” The FASEB Journal 27, no. 878.6 (2013).
  • Camilla F. Wenceslau et al., “Activation of Formyl Peptide Receptors Induces Relaxation and Reduces Contraction in Resistance Arteries.” The FASEB Journal 27, no. 1131.11 (2013).
  • Cameron G. McCarthy et al., “Chloroquine Treatment Increases the Threshold of Aortic Contractile Responses to Nor Epinephrine in a Nitric Oxide Synthase-Dependent Manner in Spontaneously Hypertensive Rats.” Hypertension 62, no. A243 (2013).
  • Meir Steiner et al., “Validating the Need for Uniform on Reproductive History for Women in Clinical Cardiovascular Studies and Database.” Journal of Women’s Health 23, no. 4 (2014).
  • Meir Steiner, Lauren Wright, and William Simpson, “The Impact of Pre-pregnancy Body Mass Index on Autonomic Function and Circadian Behaviours during Pregnancy.” Journal of Women’s Health 23, no. 4 (2014).
  • Nanette K. Wenger et al., “Optimizing Cardiovascular Disease Research in Women.” Circulation:  Cardiovascular Quality and Outcomes 7 (2014): A341.

Poster Presentations

  • “Hypertensive Pregnancy Disorders as a Risk Factor for Future Renal Disease: A Population Based Study.” Presented at the American Society of Nephrology Meeting, San Diego, CA, November 2, 2012. Authors: Andrea G. Kattah, Brown CM, Katusic S, Leibson CL, Ransom J, Weaver AL, Virginia M. Miller, Roger VL, and Vesna D. Garovic.
  • “Chronic Toll-like receptor 9 activation mediates heightened vascular contractility via attenuated NOS activity in isolated aortic segments.” Presented at the American Society for Pharmacology and Experimental Therapeutics (ASPET) Annual Meeting at Experimental Biology, Boston, MA, April 20-24, 2013. Authors: Cameron G. McCarthy, Styliani Goulopoulou, Camilla F. Wenceslau, Takayuki Matsumoto, and R. Clinton Webb.
  • “Activation of formyl peptide receptors induces relaxation and reduces contraction in resistance arteries.” Presented at the American Society for Pharmacology and Experimental Therapeutics (ASPET) Annual Meeting at Experimental Biology, Boston, MA, April 20-24, 2013. Authors:  Camilla F. Wenceslau, Cameron G. McCarthy, Styliani Goulopoulou, R. Clinton Webb.
  • “Chloroquine treatment increases the threshold of aortic contractile responses to nor epinephrine in a nitric oxide synthase-dependent manner in spontaneously hypertensive rats.”  Presented at the Council for High Blood Pressure Research Meeting, New Orleans, LA, September 11-14, 2013. Authors: Cameron G. McCarthy, Styliani Goulopoulou, Camilla F. Wenceslau, Kathryn M. Spitler K, Matsumoto, Takayuki, Webb CR.
  • “Toll-like Receptor 9 Activation Mediates Augmented Aortic Contractile Responses via Attenuated NO and Exacerbated ROS Generation.” Presented at the Southern Translation Education and Research Conference (STaR), Augusta, GA, September 26-27, 2013. Authors: Cameron G. McCarthy, Styliani Goulopoulou, Camilla F. Wenceslau, Takayuki Matsumoto, and R. Clinton Webb.
  • “Validating the need for uniform on reproductive history for women in clinical cardiovascular studies and databases.” Presented at the 22nd Annual Women’s Health Congress, Washington, D.C., April 4-6, 2014. Authors: Meir Steiner, Virginia M. Miller, Vesna D. Garovic, Janet Rich-Edwards,  Monica P. Mallampalli, C. Noel Bairey Merz, Sarah L. Berga, Jane Reckelhoff, Doris A. Taylor, Nanette K. Wenger,  and Pamela Ouyang.
  • “The impact of pre-pregnancy body mass index on autonomic function and circadian behaviours during pregnancy.” Presented at the 22nd Annual Women’s Health Congress, Washington, D.C., April 4-6, 2014). Authors: Meir Steiner M, Lauren Wright, and William Simpson.
  • “Optimizing cardiovascular disease research in women.” Presented at the Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke Conference, Baltimore, MD, June 3, 2014. Authors: Pamela Ouyang, Nanette K. Wenger, Doris A. Taylor, Jay R. Kaplan, Jane F. Reckelhoff, Janet Rich-Edwards, Meir Steiner, C. Noel Bairey Merz, Virginia M. Miller, Leslee J. Shaw, Sarah L. Berga, and R. Clinton Webb

Oral Presentations and Symposia

  • “Physiology of Cardiovascular Disease: Gender Disparities.” Presented at the American Physiological Society (APS) Meeting, Co-sponsored by SWHR. Jackson, MS, October 12-14, 2011. Organizers: Jane Reckelhoff and Meir Steiner. Presenters: Sarah L. Berga, C. Noel Bairey Merz, Pamela Ouyang, Janet Rich-Edwards, Doris A. Taylor, Meir Steiner, and Nanette K. Wenger.
  • Multiple presentations at the Organization for the Study of Sex Differences (OSSD) Sixth Annual Meeting, Baltimore, MD, June 7-9, 2012. Organizer: Virginia Miller. Presenters: C. Noel Bairey Merz, Pamela Ouyang, and R. Clinton Webb.

SWHR 2015 Symposium

  • “Transforming Cardiovascular Disease Prevention for Millennial Women: Beyond Traditional Risk Factors”
  • SWHR’s Interdisciplinary Cardiovascular Disease Symposium was held in Winston-Salem, NC, on October 7-8, 2015. The interactive symposium explored reproductive, immunological, and psychosocial risk factors for CVD in millennial women.
  • Dr. Nanette Wenger, professor of medicine in the Division of Cardiology at Emory University School of Medicine and a member of the CV Network, gave the capstone presentation entitled “Women, Research, and Cardiovascular Disease” which explored the progress that has been made toward bettering our understanding of women and cardiovascular disease.  Click here to see Dr. Wenger’s presentation.
  • Meeting Organizers: Monica P. Mallampalli, Nanette K. Wenger, Doris A. Taylor, Pamela Ouyang, Virginia M. Miller, C. Noel Bairey Merz, Meir Steiner, Sarah L. Berga and Jay R. Kaplan.

SWHR-Funded Projects 

  • “Literature review of maternal recall.” Awarded to Janet Rich-Edwards, 2011.
  • “Does pre-eclampsia predispose females to early cardiovascular-renal disease with aging?” Awarded to Jane F. Reckelhoff, 2011-2012.
  • “Sex-specific genetic variability in mechanistic pathways and cardiovascular outcomes in women with non-obstructive coronary disease.” Awarded to C. Noel Bairey Merz and Rhonda Cooper-DeHoff, 2011-2012.
  • “Hypertensive pregnancy disorders as risk factors for future cardiovascular disease in mothers and offspring.” Awarded to Virginia M. Miller and Vesna D. Garvoic, 2011-2013.
  • “Does vascular dysfunction precede preeclamptic pregnancy? Feasibility of arterial tonography in a pre-pregnancy cohort.” Awarded to Janet Rich-Edwards, 2011-2014.
  • “Cardiotonic steroids and vascular complications of preeclampsia.” Awarded to R. Clinton Webb, 2012-2014.
  • “Estrogen deficiency and cardiovascular disease biomarkers in premenopausal women.” Awarded to C. Noel Bairey Merz; Collaborator: Chrisandra Shufelt, 2012-2015.
  • “Stress immune system functioning and postpartum depression: The impact of heightened systemic inflammation and inflammation and risk of CVD later in life.” Awarded to Meir Steiner, 2012-2015.
  • “Validation of overlap among pregnancy conditions with preeclampsia.” Awarded to Virginia M. Miller; Collaborator: Vesna D. Garovic, 2013-2014.

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