2003 –2009

Mission Statement

Advance the understanding of sex-dependent differences in energy homeostasis and metabolic disorders.


  • Joel K. Elmquist, DVM, PhD, University of Texas Southwestern Medical Center (Network Chair)
  • Jeffrey Chang, MD, University of California, San Diego
  • Deborah J. Clegg, PhD, Cedars-Sinai Medical Center
  • Susan K. Fried, PhD, Boston University
  • Nori Geary, PhD, Swiss Federal Institute of Technology
  • Kevin L. Grove, PhD, Oregon Health & Science University
  • Jennifer C. Lovejoy, PhD, University of Washington
  • Randy J. Seeley, PhD, University of Michigan School of Medicine
  • Philipp E. Scherer, PhD, University of Texas Southwestern Medical Center
  • Richard B. Simerly, PhD, Vanderbilt University
  • Steven R. Smith, MD, Sanford-Burnham Medical Research Institute

Peer-reviewed Publications

  • Magdalena Pasarica, et al., “Reduced Adipose Tissue Oxygenation in Human Obesity: Evidence for Rarefaction, Macrophage Chemotaxis, and Inflammation Without an Angiogenic Response.” Diabetes 58, no. 3 (2009): 718-725. PMID:19074987
  • Helen H. Wang et al., “New Insights into the Molecular Mechanisms Underlying Effects of Estrogen on Cholesterol Gallstone Formation.” Biochimica Biophysica Acta – Molecular and Cell Biology of Lipids 1791, no. 11 (2009): 1037-1047. PMID:19589396
  • Suhuan Liu et al., “Importance of Extranuclear Estrogen Receptor-a and Membrane G Protein-Coupled Estrogen Receptor in Pancreatic Islet Survival.” Diabetes 58 (2009): 2292-2302. PMID:19587358
  • P. Nedungadi and Deborah J. Clegg, “Sexual Dimorphism in Body Fat Distribution and Risk for Cardiovascular Diseases.” Journal of Cardiovascular Translational Research 2 (2009): 321-327. PMID:20560019
  • Lynda M. Brown and Deborah J. Clegg, “Central Effects of Estradiol in the Regulation of Adiposity.” The Journal of Steroid Biochemistry and Molecular Biology 122, no. 1-3 (2010): 65-73. PMID:20035866
  • Lynda M. Brown et al., “Metabolic Impact of Sex Hormones on Obesity.” Brain Research 1350 (2010): 77-85. PMID:20441773
  • Kevin L. Grove et al., “A Microarray Analysis of Sexual Dimorphism of Adipose Tissues in High-fat-diet-induced Obese Mice.” International Journal of Obesity (London) 34, no. 6 (2010): 989-1000. PMID:20157318


  • “Preliminary Analysis of the Mouse Gene Expression Data.” Keystone Symposia at Molecular Control of Adipogenesis and Obesity, Banff, Alberta, Canada, February 19-24, 2008. Presenters: Deborah J. Clegg and Kevin L. Grove
  • “Sex and Obesity: Gender Differences in Energy Homeostasis and Fat Metabolism.” Symposia at the International Association for the Study of Obesity Stock Conference, March 2008. Presenters: Jennifer C. Lovejoy, Susan K. Fried, Steven R. Smith, and Nori Geary.

SWHR-Funded Projects

  • “Sex differences in gene expression in murine adipose tissue: Parts I and II.” Awarded to Deborah J. Clegg, Randy J. Seeley, and Kevin L. Grove, 2006-2010.
  • “Sex differences in gene expression in human adipose tissue.” Awarded to R. Jeffrey Chang, Susan K. Fried, Jennifer C. Lovejoy, and Steven R. Smith, 2007-2008.
  • “Sex differences in adipose tissue miRNAs.” Awarded to Steven R. Smith and Susan K. Fried, 2010-2012.