Karen Reue, PhD, is Professor of Human Genetics in the Geffen School of Medicine, University of California, Los Angeles and director of an National Institutes of Health (NIH) Scientific Center of Research Excellence on Sex Differences in Cardiometabolic Health and Disease. The Reue laboratory is interested in the identification of genes, pathways, and the role of sex in the development of cardiometabolic diseases including obesity, fatty liver, and atherosclerosis. A key finding has been the importance of both gonadal hormones and sex chromosome gene dosage in sex-biased functions in adipose tissue and obesity, regulation of lipid metabolism, mitochondrial function, and drug adverse effects.